GitHubGitHub

FeaturesPlatform Features

Roadmap

Short Term

  • Agentic Control - AI-driven research workflow management
  • Milestone-based Planning - Enhanced project timeline tracking

Long Term

  • 🔮Federated multisite research collection
  • 🔮Evidence extraction, standardization and exchange
  • 🔮Multisite Networking - Research collaboration across institutions

Privacy: Our Central Pillar

Privacy
Complete Privacy Control

Healthcare research demands the highest standards of privacy protection. CareFrame makes privacy a central pillar of our platform, with advanced PHI/PII detection and protection built into every aspect.

  • 🔒Advanced PHI/PII detection and redaction
  • 🔒HIPAA and PHIPA compliant by design
  • 🔒Granular privacy controls for each project

Security
Secure Deployment Options

Deploy CareFrame entirely within your institutional firewall, with no external dependencies required.

  • 🛡️Run locally within your firewall
  • 🛡️Use open-source LLMs for complete data sovereignty
  • 🛡️No data ever leaves your secure environment

StrategyResearch Strategy

Planning

Planning

Visual canvas for mapping research objectives and hypotheses

Research Canvas

Research Canvas

Interactive visual workspace for research planning

Objective Management

Objective Management

Hierarchical organization of research objectives

Hypotheses

Hypotheses

Create and manage testable research hypotheses

Hypothesis Generator

Hypothesis Generator

AI-assisted creation of research hypotheses

Hypothesis Testing

Hypothesis Testing

Connect hypotheses to evidence and statistical tests

Study Design

Study Design

Design and plan research studies

Protocol Development

Protocol Development

Create detailed study protocols from evidence

Session Management

Session Management

Organize and manage research projects

Team Management

Team Management

Manage research team members and permissions

EvidenceEvidence Management

LiteratureLiterature Evidence

Literature Search

Literature Search

Find and collect relevant research papers

Paper Ranking

Paper Ranking

Sort literature by relevance to hypotheses

Evidence Extraction

Evidence Extraction

Extract claims and evidence from papers

DataData-Based Evidence

Data Sources

Data Sources

Connect to various data collection sources

Model Testing

Model Testing

Statistical testing of research hypotheses

Result Interpretation

Result Interpretation

Visualize and interpret statistical results

ValidationEvidence Validation

Evidence Blockchain

Evidence Blockchain

Secure, immutable storage of research evidence

Validator Management

Validator Management

Team-based validation of research evidence

Proof Authority

Proof Authority

Cryptographic verification of evidence provenance

DataData Management

Data Cleaning

Data Cleaning

Tools for preparing and cleaning research data

Data Reshaping

Data Reshaping

Transform data structures for analysis

Data Filtering

Data Filtering

Select relevant subsets of research data

Data Merging

Data Merging

Combine data from multiple sources

Database Management

Database Management

Configure and manage research databases

AnalysisStatistical Analysis

Assumption Checking

Assumption Checking

Validate statistical assumptions for tests

Advanced Analysis

Advanced Analysis

Specialized statistical techniques

Subgroup Analysis

Subgroup Analysis

Examine effects within population subgroups

Mediation Analysis

Mediation Analysis

Test for mediating relationships between variables

Sensitivity Analysis

Sensitivity Analysis

Test robustness of findings to assumptions

Biomedical Annotation

Biomedical Annotation

Annotate medical terms in research documents

ManagementStudy Management

Participant Management

Participant Management

Track study participants and data collection

Documentation

Documentation

Maintain comprehensive study documentation

Network Sharing

Network Sharing

Share evidence and protocols across institutions

Documentationdocumentation / user guidesResearch Planning Guide

Research Planning Guide

Research Planning Guide

Overview

The Research Planning module provides a visual canvas for defining, organizing, and tracking your research objectives and hypotheses. It helps you build a structured research plan that can be shared, modified, and tracked throughout your study.

Research Planning Interface

Key Concepts

  • Objectives: The core questions or goals of your research
  • Sub-objectives: More specific goals that support the main objectives
  • Hypotheses: Testable predictions that can be validated through research
  • Evidence: Data that supports or refutes hypotheses

Interface Components

The Research Planning interface consists of:

  1. Control Panel (left side)

    • Objective controls
    • Hypothesis controls
    • View options
  2. Visual Canvas (right side)

    • Interactive nodes representing objectives and hypotheses
    • Connections showing relationships between elements
    • Type lanes for organizing different node types
  3. Evidence Panel (bottom right, appears when a hypothesis is selected)

    • Literature evidence
    • Statistical evidence
    • Other evidence types

Basic Workflow

1. Create a Research Objective

  1. Click the Add Objective button (bullseye icon)
  2. Enter your research question or goal
  3. Select the appropriate objective type:
    • Research Question
    • Goal
    • Problem Statement
    • Other

2. Add Sub-objectives (Optional)

  1. Select an existing objective
  2. Click the Add Sub-objective button (diagram icon)
  3. Enter details for the sub-objective
  4. Position it on the canvas in relation to the parent objective

3. Create Hypotheses

For each objective or sub-objective:

  1. Select the objective
  2. Click the Add Hypothesis button (lightbulb icon)
  3. Enter your hypothesis statement
  4. Define variables if applicable
  5. Position it on the canvas

4. Generate Hypotheses with AI

For automated hypothesis generation:

  1. Select an objective
  2. Click the Auto-Generate Hypotheses button (CPU icon)
  3. Review the generated hypotheses
  4. Keep or discard as appropriate

5. Manage Evidence

For each hypothesis:

  1. Select a hypothesis node
  2. Click the Manage Evidence button (journal icon)
  3. Add literature evidence from the Literature Search module
  4. Add statistical evidence from the Data Analysis module
  5. Add other types of evidence as needed

Advanced Features

Auto-arrange Layout

Click the Auto Arrange button to organize your research plan elements in a clean, hierarchical layout.

Lane Organization

Use the Create Type Lanes button to organize nodes by type (objectives, hypotheses) in vertical lanes.

Importing from Studies

If you already have studies in the Studies Manager, click Import from Studies Manager to create a research plan based on existing study designs.

Auto-Generate and Test

Use the Auto-Generate and Test feature to have the AI create hypotheses and immediately test them against available data.

Example Workflow

  1. Create a primary research objective: "Investigate the effect of medication adherence on blood pressure control in hypertensive patients"
  2. Add sub-objectives:
    • "Identify factors affecting medication adherence"
    • "Quantify the relationship between adherence and blood pressure"
  3. Generate hypotheses for each sub-objective
  4. Collect evidence from literature search
  5. Test hypotheses with patient data
  6. Update hypothesis states based on evidence

Tips and Best Practices

  • Start with broad objectives and refine into more specific sub-objectives
  • Create clear, testable hypotheses that specify relationships between variables
  • Use the AI generator for inspiration but review all suggestions carefully
  • Connect your hypotheses to literature evidence before testing with data
  • Update hypothesis states (validated, rejected, inconclusive) as new evidence emerges

Next Steps

After completing your research plan, you can:

  • Navigate to Literature Search to find supporting evidence
  • Use the Protocol section to define your study protocol based on the plan
  • Set up Data Collection to gather data for testing your hypotheses
  • Return to the Research Plan to update hypothesis states as your research progresses

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